Dr. Laurie Graham – Senior Research Associate (more)
Dr. Qilu Ye - Research Associate (more)
Robert Eves – Research Assistant (more)
Sherry Gauthier – Research Assistant (part-time)
Connor Scholl – PhD candidate (more)
Mathias Bell - MSc candidate (more)
Jordan Forbes - MSc candidate (more)
Thomas Hansen - MSc candidate (more)
Emily Lind - MSc candidate (more)
Mustafa Sherik - MSc candidate (more)
Mary Yang - MSc candidate (more)
Adam Khan - BSc Hons candidate (more)
Jocelyn Lee - BSc Hons candidate (more)
Lorenzo Sivilotti - BSc Hons candidate
Dr. Laurie Graham
Senior Research Associate and Adjunct Assistant Professor
I am writing Laurie’s bio because she is too modest to do justice to her many talents and the huge contribution she makes to the smooth running of our lab. Laurie completed her PhD with Dr. Virginia Walker in the Department of Biology at Queen’s and joined us for post-doc research in the 1990’s when we were beginning to isolate and characterize insect antifreeze proteins. Since then, we have published close to 40 papers together including a couple in Science and Nature. Laurie is an expert in molecular biology from the ‘pre-kit’ days. Her amazing skills in bioinformatics are helping us mine the wealth of genomic and transcriptomic data that is being deposited every year. In addition to being a rigorous scientist, Laurie is a spouse, mom, hockey player, and a life-long learner with a passion for science, astronomy, minerology, oceanography, and nature. /Peter Davies
Photo credit: Thomas Hansen
Hi, my name is Rob. I have worked in the department with many of the current and former members of the Davies Lab members since 1999. In 2016, with Sherry Gauthier's 'semi-retirement', I joined the Davies lab as full-time Research Assistant. I help to keep the lab running smoothly by ordering supplies, maintaining and repairing equipment, and ensuring Health and Safety compliance through persononnel training and updating standard operating procedures. My roles include being familiar with all techniques and protocols used by the Davies lab to ensure that knowledge remains with the lab when researchers move on. I help train newcomers to the lab in techniques and protocols. My current research projects include studying the structure-function relationships of ice-binding proteins, and the use of antifreeze proteins for cell, tissue and organ preservation.
Dr. Qilu Ye
In Dr. Davies' Lab, I specialize in using X-ray crystallography and complementary small-angle X-ray scattering to study structure-functional relationship in a variety of proteins. These include the calpain family of calcium-dependent proteases, ice-binding proteins and bacterial adhesins. My research generally starts with recombinant protein production and purification, protein crystal growth, followed by solving the protein structure. The 3D-structures provide valuable information for further investigations on these proteins by our group. Although the path to determine the protein crystal structure is not even, I truly like science and enjoy my research achievements. My hobbies include swimming and gardening.
Hello! My name is Connor and I am a PhD student in the Davies lab. I completed my undergraduate degree here at Queen's in Biochemistry, but four years wasn't enough time here! My current research involves identifying and characterizing antifreeze proteins from different Collembola (springtails) all over the world. Using ice-affinity chromatography we can collect the native AFP proteins to look at their activity, sequence, and structure. From this gold-mine of AFPs we hope to characterize new families of AFPs that may be used in cryotechnologies. You can often find me scorekeeping and full of school sprit at Queen's Gaels sporting events!
Hello, my name is Mathias, and I am a Masters student in the Davies lab. I grew up on Vancouver Island on the west coast. After completing an undergraduate biochemistry degree in the French Immersion stream at the University of Ottawa, I came to Queen’s to pursue graduate studies. My research focuses on calpain-3, a member of the calpain family of proteases with a series of unique sequence features. We are studying the interaction between calpain-3 and titin and how calpain-3’s unique sequence features are involved in this interaction. When not working in the lab, I enjoy reading, playing piano, and hiking in Frontenac Park.
Hi! I’m Jordan, a 2nd year Master’s student who - like many on the 6th floor of Botterell Hall - completed a biochemistry undergrad degree at Queen’s. My research project explores a protein responsible for the lesser-known phenomenon of bacterial ice nucleation. Approximately 10 Gram-negative species express ice nucleation proteins (INPs) on their outer membranes to organize water molecules in an ice-like manner, thereby nucleating freezing in the extracellular milieu. Ice-nucleating bacteria, of which Pseudomonas syringae is the most well researched, can be found on the surfaces of plants, where ice formation enables plant nutrient access. The function of INPs is therefore opposite to that of antifreeze proteins, indicating that nature has evolved elegant ways to both initiate and resist ice formation. In my spare time, I enjoy most sports (Peter and I make a good tennis duo, though I’m definitely not the one with the team on my shoulders), video games, bike rides, and cooking - or really the end result, which is eating!
My name is Thomas Hansen and I'm a Master's student in the Davies Lab. After obtaining my BSc in biochemistry from the University of Ottawa, I taught high school biology in Colombia for six years, the last four of which were with Colegio Colombo Británico, an IB academy in Cali. ¡Cali es Cali! It had always been my intention to continue my education, so in being here, I'm living the dream! I'm working with ice nucleation proteins (INPs), which as their name suggests, nucleate ice crystal formation at temperatures as warm as -2 °C. INPs have been studied for decades but to date, no one has solved their structure nor their mechanism. I'm doing my best to change that, so I've been at the bench doing functional work and behind the keyboard running simulations. Collaborating with the other talented people on this page has been invaluable in progressing toward our goals.
Hi, I’m Emily and I am an MSc student in the Davies lab. I also completed my undergraduate degree at Queen’s in Biochemistry, during which time I participated in an internship at a pharmaceutical company. Currently, I am researching the evolution of type II antifreeze proteins in fish. We are interested in learning how highly similar, lectin-like antifreeze proteins evolved to be present in several divergent fish species. This investigation will provide valuable information on how gene duplication and dissemination occur in vertebrate species. Aside from my lab duties, I volunteer as the managing editor of the Canadian Science Fair Journal, which publishes the work of students in grade and high school via an age-appropriate peer reviewed process.
Hello! My name is Mustafa Sherik and I am a MSc student in the Davies lab. I completed my undergraduate here at Queen’s University in Biochemistry. My research involves structurally characterizing pathogenic bacterial adhesins using X-ray crystallography and identifying potential ligand inhibitors using various ligand-binding assays. Currently, I am working with adhesins of Vibrio cholerae and Uropathogenic Escherichia coli. When I am not in the lab working on adhesins, you can find me playing soccer, watching movies, or taking long walks by the lake!
Hello! I’m Mary, a 1st year MSc student who joined the Davies lab in summer 2020. I came to Canada during high school and finished my biochemistry undergrad degree at McGill. My research project is on plant bacterial adhesins, which are large, multidomain proteins that bacteria uses to attach to plant root surfaces and form biofilms. Their functions include promoting plant growth and preventing pathogenic fungal infection.. Recently we are focusing on the large adhesion protein family (Lap) from Pseudomonas fluorescens, but we are also studying other exciting adhesin systems in nature.I am particularly interested in the structure of the adhesin ligand-binding domains and identification of the substrates to which they bind. During my spare time, I enjoy music, films, and watching soccer (officially signed up for Bayern Munich membership from Jan 2021!)
BSc Hons Candidate
Hello, my name is Adam Khan and I am in my fourth year of the Life Sciences Specialization program at Queen's. I am currently working on my 499-project (undergraduate-level thesis) under Connor's wing. My project involves determining amino acid residues involved in ice-binding of a Japanese snowflea's AFP! I express mutants of the AFP, and subsequently determine the thermal hysteresis to compare it to the wild-type protein. My friends and colleagues tend to describe me as being the "life of the party."
BSc Hons Candidate
Hi! I'm Jocelyn, a Life Sciences Specialization undergraduate student completing my final year here at Queen's. I am from Markham, Ontario, although I spent my early childhood between Taiwan and Canada. Before joining the Davies lab as a thesis project student, I interned for 16 months at a vaccine company. I also studied abroad in Japan as part of a program centred around intercultural business and collaboration. My 4th-year thesis project involves examining ice nucleation proteins, which are produced by certain species of Gram-negative bacteria. When I'm not working, you'll find me making music, playing video games, or cheering on the Toronto Raptors!