Davies Lab Volleyball game
Oct. 1, 2021
The first Davies Lab social since the pandemic took place Friday afternoon with a friendly volleyball game at Lake Ontario Park. The score was win-win for all, with star players on both sides of the net. The teams, joined by a few working lab members, then convened at Peter and Lucy's for some outdoor, distanced, non-contact refreshments. 

















































































 

IMG_7438.jpg
IMG_7441.jpg
IMG_7450.jpg
IMG_7452.jpg
IMG_7457.jpg
IMG_7454.jpg
IMG_7465.jpg
IMG_7471.jpg
 
 

March 22, 2021

Congratulations to Laurie Graham on her recent publication in Trends in Genetics. This FOCUS article advances our research on the horizontal transfer of lectin-like antifreeze protein genes between fish species. Using the recently sequenced herring genome, Laurie was able to prove that the gene has jumped from herring to smelt. Surprisingly, the antifreeze gene did not start out in the herring but was transferred in from another fish species that we are trying to identify.

This research advance is the subject of a news article released today by Queen’s University. The publication, “Horizontal Gene Transfer in Vertebrates: A Fishy Tale”, is available through open access in the March issue of Trends in Genetics and is also available online and from PubMed. Our colleague, Thomas Hansen, has prepared a YouTube video explaining this discovery in the context of genetic modification of organisms.

The story has been picked up by CBC, Quanta Magazine, and The Atlantic. 

 

January 18, 2021

Congratulations to Connor Scholl on his recent publication in FEBS. J. that reports the crystal structure of a snow flea antifreeze protein and its arrangement of ice-like surface waters. This is the result of a collaboration with our dear colleague, Professor Sakae Tsuda, who with his wife Harumi, collected this Collembola species near Sapporo, Japan and showed that it contained a potent antifreeze activity.

FEBS J. 2021 Jan 18.
doi: 10.1111/febs.15717. Online ahead of print.
Crystal waters on the nine polyproline type II helical bundle springtail antifreeze protein from Granisotoma rainieri match the ice lattice
Connor L Scholl 1 , Sakae Tsuda 2 , Laurie A Graham 1 , Peter L Davies 1
Affiliations
PMID: 33460499
DOI: 10.1111/febs.15717


 

 

Jack o'lanterns, local band, and where's Peter?

October 31, 2019

IMG_1905.jpg
IMG_1908.jpg
IMG_1925.jpg
IMG_1923.jpg
IMG_1927.jpg
IMG_1917.jpg
IMG_5886a.jpg
IMG_3181.jpg
IMG_3180.jpg

Fall Hike in Frontenac Park

Saturday Oct. 26, 2019

A beautiful fall hike in Frontenac Provincial Park, on the southern edge of the Canadian Shield. We picked a perfect day for some fresh air, sunshine, exercise, and picnic! (Photo credits Pooja and Peter)

IMG_1884.jpg
IMG_1888.jpg
IMG_1885.jpg
IMG_20191026_105935.jpg
IMG_20191026_112131.jpg
IMG_1887.jpg
MVIMG_20191026_141346.jpg
 
 

Congratulations Dr. Saeed Yazdi

Sept. 18, 2019

We gathered for another PhD defense celebration with Key lime pie - the third in 12 months. This one was in honour of Dr. Saeed Rismani Yazdi, our expert in microfluidics, who successfully defended in August. The pot luck was attended by the newly wedded Tyler and Lauren, who are in the process of moving to Toronto where Tyler will be a PDF in Jeff Lee's lab. It was also our opportunity to welcome to the lab two new Honours project students, Jenny Min and Emily Lind, and our new graduate student, Jordan Forbes. Welcome Jenny, Emily, and Jordan!

IMG_1604.jpg
IMG_1610.jpg
IMG_1622.jpg
IMG_1618.jpg
IMG_1624.jpg
IMG_1633.jpg
IMG_1637.jpg

 

 

 

Congratulations Dr. Tyler Vance!

May 10, 2019

Tyler defended his PhD thesis with aplomb! and the entire Davies lab celebrated his success with GUSTO! A hearty dinner was topped off with Peter's specialty PhD Key Lime Pie, of course. #tradition Congratulations and all the best in Toronto, Dr. Vance!

DSCF6812.jpg
DSCF6813.jpg
IMG_1165.jpg
DSCF6885.jpg
DSCF6820.jpg
 
DSCF6876.jpg
DSCF6854.jpg
IMG_1168.jpg
IMG_1621.jpg
 

Biochem Body Pump Challenge!

July 12, 2019

This was the 3rd of our 4-yearly Body Pump Challenges for the Biochem program. Great turnout ... but sadly, the Davies lab was just beaten on percent attendance by the Allingham lab. Well done Allinghammers! Thanks and congrats to all the pumpers, and thanks to super instructor Anna Coe and GoodLife for their support.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Hawaiian shirt Ice Cream Day

July 10, 2019

Incoming Lab Social Convener Brett's inaugural event! Yum!!

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Lab Bowling Night

Jan. 21, 2019

Lab Bowling Night with colleagues from the 6th floor. Celebrity bowlers include: Midnight Cowboy, Falling Star, Marie Let Them Eat Cake, Cosmo Kramer, and Mitch Marner. Thank you to Social Convener Tyler for organizing indoor bowling on the coldest night of the year.

 
IMG_1383.jpg
IMG_1385.jpg
IMG_1388.jpg
IMG_1393.jpg
IMG_2307.jpg
IMG_2306.jpg
 
IMG_5456.jpg
IMG_5457.jpg
IMG_5468.jpg

Brett at the Brooklyn

Nov. 8, 2018

Who purifies proteins and does PCR by day, and plays in a band by night? Why, Brett Kinrade - of course! Knowing how good his lab work is, we went to check out the music. He rocks at both!

 
IMG_0113 - Copy.jpg
IMG_0121.jpg
IMG_0120.jpg
IMG_0126.jpg
 

Lab hike in Frontenac Park 

Sunday Nov. 4, 2018

We had lovely late fall weather for our 13-km hike around Slide Lake to enjoy Canadian Shield scenery.

Photo credits: Marie and Cristina.

IMG_20181104_105940.jpg
IMG_20181104_124107.jpg
DSC06841 (1).jpg
DSC06820.jpg
DSC06779.jpg
DSC06768.jpg
DSC06925.jpg
 

Congratulations Dr. Christian McCartney!

October 19, 2018

Congratulations to Christian McCartney on the successful defense of his PhD thesis! We were honoured to have Dr. Yasuko Ono who came all the way from the Tokyo Metropolitan Institute of Medical Science in Japan to visit us and serve as Christian's external examiner. On the evening of the defense we gathered for a potluck dinner celebration, with scotch and sake tasting, and the traditional Key lime pie for the new Doctor of Philosophy.

IMG_0638.jpg
DSCF4603.jpg
DSCF4591.jpg
DSCF4611.jpg
IMG_0634.jpg
DSCF4616.jpg
IMG_0642.jpg
DSCF4675.jpg
DSCF4621.jpg

 

 

Advances in Molecular Biology 2018 Symposium

Donald Gordon Centre, Queen's University

 

August 3 - 4, 2018

To celebrate Sherry Gauthier's semi-retirement after over 30 years as chief lab technician, mentor, and den mother, Peter organized a Symposium in her honour. Over 40 lab alumni travelled across the globe for this wonderful occasion - from Australia, New Zealand, Singapore, Switzerland, California, Tennessee, Ohio, British Columbia, Alberta, Quebec and Ontario! Four sessions of illuminating talks on topics ranging from tumour microenvironment to gene therapy, from wheat fungi to human microbiomes. The fun continued with a Davies Lab traditional croquet game complete with pink flamingos courtesy of Dr. Pliny Hayes. Family and friends joined the Friday dinner, and Sherry was deservedly serenaded and thanked and hugged for her help and support over the years. Saturday afternoon ended with a nostalgia tour of the sixth floor of Botterell Hall! Thank you to everyone for coming from far and wide for this memorable lab reunion celebration!

DSCF2748.jpg
DSCF2837.jpg
DSCF3411.jpg
DSCF2901.jpg
DSCF3096.jpg
DSCF3176.jpg
DSCF3133.jpg

 

 

Tribute to Gordon H. Dixon

September 2018

 

Some background to “Protein Evolution Revisited” by Peter L. Davies* and Laurie Graham – published September 2018 (PMID: 30176752).

In recognition of the lifework of Dr. Gordon H. Dixon (1930/03/25 – 2016/07/24), two of Gordon’s former trainees - Rafael Oliva and Stephen A. Krawetz - commissioned a Special Issue of Systems Biology in Reproductive Medicine in his memory. Peer-reviewed papers were contributed by researchers who trained in the Dixon lab, or were collaborators. The modified preface to our review (below) also gives an insight into how we came to work on antifreeze proteins.

 

Peter Davies:  Gordon H. Dixon (GHD), one of my post-doctoral mentors, wrote an inspiring review on “Mechanisms of Protein Evolution” in the 1966 2nd edition of ‘Essays in Biochemistry’. It was written only thirteen years after the discovery of double helix DNA structure, at a time when the genetic code had just been deciphered, nucleic acid sequencing was tortuous, and protein sequencing was THE way to study gene variation and mutation. GHD was able to capture the emerging field of molecular biology in this article and illustrate how protein evolutionary mechanisms were being deduced from tiny amounts of data. I read “Mechanisms of Protein Evolution” as an undergraduate student at University of Wales, UK and was fascinated by the emerging links between protein divergence and the evolution of species. GHD’s review encouraged me to continue the study of biochemistry at the graduate level, which led in turn to a career in research.  In 1968, I was accepted into the graduate program in the Department of Biochemistry at the University of British Columbia, not realizing that GHD had moved there from Toronto. When I found out he was in the department I was told Gordon’s lab was full. Indeed it was crowded, and I remember at one point a post-doctoral fellow using the ultracentrifuge as a desk, hoping that the rotors were well balanced. I made many friends in his lab and followed their work on rainbow trout spermatogenesis, histone modification and protamine expression with great interest.

My opportunity to work with Gordon came in 1974 as a post-doctoral fellow when GHD returned to Canada from Sussex, UK to set up a new lab at the University of Calgary’s Medical School next to the Foothills Hospital. By this time it was realized that eukaryotic messenger RNAs had poly (A) tails and the isolation of protamine mRNA had been achieved and perfected in the GHD lab by Lashitew Gedamu. One of the collaborative projects that I worked on with Lashitew in Calgary was a study of the proteins bound to protamine mRNA that formed messenger ribonucleoprotein particles. My planned project as a new independent investigator and Assistant Professor at Queen’s University (Kingston, ON) in 1977 was an examination of messenger ribonucleoprotein particles in developing muscle. But a friendship formed at UBC with one of GHD’s graduate students, Choy-Leung Hew, changed all that. Choy had worked with Gordon on haptoglobins and was an expert in protein chemistry. He joined the faculty at Memorial University of Newfoundland in 1974, and soon after developed an interest in the recently discovered antifreeze proteins (AFPs) of marine fishes.  Choy recruited me to the study of AFPs to assist with the molecular biology aspects because I had gained experience in mRNA isolation, cDNA synthesis, and nucleic acid sequencing from my research with GHD in Calgary. It was a fortuitous transition as AFPs have been an extremely productive field for investigating protein structure-function relationships. However, some of the most fascinating insights about antifreeze proteins are those that relate to protein evolution - the theme of the review article GHD wrote over 50 years ago that is echoed here. Our review on protein evolution features examples from the field of antifreeze proteins, but with some parallels to protamines.